{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:29:10Z","timestamp":1787974150557,"version":"build-2784847793"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,3,25]]},"abstract":"<jats:p>\n                    Rhes (\n                    <jats:italic>RASD2<\/jats:italic>\n                    ) is a thyroid hormone\u2013induced gene that regulates striatal motor activity and promotes neurodegeneration in Huntington disease (HD) and tauopathy. Rhes moves and transports the HD protein, polyglutamine-expanded huntingtin (mHTT), via tunneling nanotube (TNT)\u2013like membranous protrusions between cultured neurons. However, similar intercellular Rhes transportation in the intact brain was unknown. Here, we report that Rhes induces TNT-like protrusions in the striatal medium spiny neurons (MSNs) and transported between dopamine-1 receptor (D1R)\u2013MSNs and D2R-MSNs of intact striatum and organotypic brain slices. Notably, mHTT is robustly transported within the striatum and from the striatum to the cortical areas in the brain, and Rhes deletion diminishes such transport. Moreover, Rhes moves to the cortical regions following restricted expression in the MSNs of the striatum. Thus, Rhes is a first striatum-enriched protein demonstrated to move and transport mHTT between neurons and brain regions, providing new insights into interneuronal protein transport in the brain.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abm3877","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T13:59:44Z","timestamp":1648043984000},"source":"Crossref","is-referenced-by-count":33,"title":["Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-1293","authenticated-orcid":true,"given":"Uri Nimrod","family":"Ram\u00edrez-Jarqu\u00edn","sequence":"first","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-4368","authenticated-orcid":true,"given":"Manish","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-4811","authenticated-orcid":true,"given":"Neelam","family":"Shahani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-5529","authenticated-orcid":true,"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, Gainesville, FL 32610, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-4056","authenticated-orcid":true,"given":"Siddaraju","family":"Boregowda","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-4953","authenticated-orcid":true,"given":"Srinivasa","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00140-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.05.027"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf6670"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51839-w"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.12.012"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172871"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.05.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","unstructured":"O. 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