{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:45:17Z","timestamp":1792169117434,"version":"4.4.0"},"reference-count":64,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,4,22]]},"abstract":"<jats:p>Brain imaging is essential to the clinical management of patients with ischemic stroke. Timely and accessible neuroimaging, however, can be limited in clinical stroke pathways. Here, portable magnetic resonance imaging (pMRI) acquired at very low magnetic field strength (0.064 T) is used to obtain actionable bedside neuroimaging for 50 confirmed patients with ischemic stroke. Low-field pMRI detected infarcts in 45 (90%) patients across cortical, subcortical, and cerebellar structures. Lesions as small as 4 mm were captured. Infarcts appeared as hyperintense regions on T2-weighted, fluid-attenuated inversion recovery and diffusion-weighted imaging sequences. Stroke volume measurements were consistent across pMRI sequences and between low-field pMRI and conventional high-field MRI studies. Low-field pMRI stroke volumes significantly correlated with stroke severity and functional outcome at discharge. These results validate the use of low-field pMRI to obtain clinically useful imaging of stroke, setting the stage for use in resource-limited environments.<\/jats:p>","DOI":"10.1126\/sciadv.abm3952","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T13:51:26Z","timestamp":1650462686000},"source":"Crossref","is-referenced-by-count":151,"title":["Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-8534","authenticated-orcid":true,"given":"Matthew M.","family":"Yuen","sequence":"first","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali M.","family":"Prabhat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercy H.","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha R.","family":"Chavva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-4446","authenticated-orcid":true,"given":"Bradley A.","family":"Cahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Beekman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-6198","authenticated-orcid":true,"given":"Jennifer A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Gobeske","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-3340","authenticated-orcid":true,"given":"Nils H.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-0302","authenticated-orcid":true,"given":"Guido J.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-3607","authenticated-orcid":true,"given":"Adam S.","family":"Jasne","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardik","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0798-2353","authenticated-orcid":true,"given":"Richa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3234-9541","authenticated-orcid":true,"given":"Charles","family":"Matouk","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-5013","authenticated-orcid":true,"given":"Adrienne","family":"Ward","sequence":"additional","affiliation":[{"name":"Neuroscience Intensive Care Unit, Yale New Haven Hospital, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-1680","authenticated-orcid":true,"given":"Lauren","family":"Sansing","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-8597","authenticated-orcid":true,"given":"Adam","family":"de Havenon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Wira","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Sze","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-002X","authenticated-orcid":true,"given":"Matthew S.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-8530","authenticated-orcid":true,"given":"W. Taylor","family":"Kimberly","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-5473","authenticated-orcid":true,"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.16.181636"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61953-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"Powers W. J.","year":"2019","unstructured":"W. J. Powers, A. A. Rabinstein, T. Ackerson, O. M. Adeoye, N. C. Bambakidis, K. Becker, J. Biller, M. Brown, B. M. Demaerschalk, B. Hoh, E. C. Jauch, C. S. Kidwell, T. M. Leslie-Mazwi, B. Ovbiagele, P. A. Scott, K. N. Sheth, A. M. Southerland, D. V. Summers, D. L. Tirschwell, Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 50, e344\u2013e418 (2019).","journal-title":"Stroke"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1608770"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60151-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90614-B"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-469"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199003000-00006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92176-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20190003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199509000-00020"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc362"},{"key":"e_1_3_3_15_2","first-page":"6847124","article-title":"Analysis of adverse events during intrahospital transportation of critically ill patients","volume":"2017","author":"Gimenez F. M. P.","year":"2017","unstructured":"F. M. P. Gimenez, W. H. B. de Camargo, A. C. B. Gomes, T. S. Nihei, M. W. M. Andrade, M. L. de A F S\u00e9 Valverde, L. D\u2019 Epiro de Souza Campos, D. C. Grion, J. Festti, C. M. C. Grion, Analysis of adverse events during intrahospital transportation of critically ill patients. Crit. Care Res. Pract. 2017, 6847124 (2017).","journal-title":"Crit. Care Res. Pract."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2020.00172"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1603"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199806000-00064"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.973"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10101157"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v8.i12.902"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5656480"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.3263"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.760321"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25441-6"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007993"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.30.240.14000"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000215876"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.03.011"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.600148"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000441153"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5787-x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.582874"},{"key":"e_1_3_3_34_2","first-page":"1399","article-title":"Imaging of ischemic stroke","volume":"22","author":"Lin M. P.","year":"2016","unstructured":"M. P. Lin, D. S. Liebeskind, Imaging of ischemic stroke. Continuum (Minneap Minn) 22, 1399\u20131423 (2016).","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018765235"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019915587227"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000114203.75678.88"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.15.1823"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2015.52"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.6.1318"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep15177"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27317-1"},{"key":"e_1_3_3_43_2","unstructured":"T. Rearick G. L. Charvat M. S. Rosen J. M. Rothberg U.S. Patent US9797971B2 (2017)."},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz106"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25988"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.568410"},{"key":"e_1_3_3_47_2","first-page":"637","article-title":"Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke","volume":"22","author":"Lansberg M. G.","year":"2001","unstructured":"M. G. Lansberg, V. N. Thijs, M. W. O\u2019Brien, J. O. Ali, A. J. de Crespigny, D. C. Tong, M. E. Moseley, G. W. Albers, Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke. Am. J. Neuroradiol. 22, 637\u2013644 (2001).","journal-title":"Am. J. Neuroradiol."},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.11.2268"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21651"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.325115760"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2016.08.016"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.016"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604267"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-102029"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46648-0"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103879"},{"key":"e_1_3_3_57_2","unstructured":"U.S. Food and Drug Administration Enforcement policy for imaging systems during the coronavirus disease 2019 (COVID-19) public health emergency: Guidance for industry and food and drug administration staff (U.S. Food and Drug Administration 2020)."},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1159\/000452634"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2622238"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2011.05.005"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200005)43:5<682::AID-MRM10>3.0.CO;2-G"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290212"},{"key":"e_1_3_3_63_2","first-page":"243","article-title":"Effect of diffusion on the steady-state magnetization with pulsed field gradients","volume":"90","author":"Wu E. X.","year":"1990","unstructured":"E. X. Wu, R. B. Buxton, Effect of diffusion on the steady-state magnetization with pulsed field gradients. J. Magn. Reson. 90, 243\u2013253 (1990).","journal-title":"J. Magn. Reson."},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.02.016"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10308"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abm3952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T16:45:06Z","timestamp":1704818706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abm3952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":64,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,4,22]]}},"alternative-id":["10.1126\/sciadv.abm3952"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abm3952","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]},"article-number":"eabm3952"}}