{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:46:47Z","timestamp":1791942407318,"version":"4.3.4"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,2,25]]},"abstract":"<jats:p>\n                    Tissue injury can drive secondary organ injury; however, mechanisms and mediators are not well understood. To identify interorgan cross-talk mediators, we used acute kidney injury (AKI)\u2013induced acute lung injury (ALI) as a clinically important example. Using kidney and lung single-cell RNA sequencing after AKI in mice followed by ligand-receptor pairing analysis across organs, kidney ligands to lung receptors, we identify kidney-released circulating osteopontin (OPN) as a novel AKI-ALI mediator. OPN release from kidney tubule cells triggered lung endothelial leakage, inflammation, and respiratory failure. Pharmacological or genetic OPN inhibition prevented AKI-ALI. Transplantation of ischemic\n                    <jats:italic>wt<\/jats:italic>\n                    kidneys caused AKI-ALI, but not of ischemic OPN\u2013global knockout kidneys, identifying kidney-released OPN as necessary interorgan signal to cause AKI-ALI. We show that OPN serum levels are elevated in patients with AKI and correlate with kidney injury. Our results demonstrate feasibility of using ligand-receptor analysis across organs to identify interorgan cross-talk mediators and may have important therapeutic implications in human AKI-ALI and multiorgan failure.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abm5900","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T14:00:32Z","timestamp":1645797632000},"source":"Crossref","is-referenced-by-count":102,"title":["Identification of kidney injury\u2013released circulating osteopontin as causal agent of respiratory failure"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-607X","authenticated-orcid":true,"given":"Fatima Zohra","family":"Khamissi","sequence":"first","affiliation":[{"name":"Washington University School in St. Louis School of Medicine, 660 S Euclid Avenue, St. Louis, MO 63110, 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