{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:29:04Z","timestamp":1790684944549,"version":"4.1.0"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,4,29]]},"abstract":"<jats:p>\n                    Malaria remains a global health problem causing more than 400,000 deaths annually.\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites, the causative agents of malaria, replicate asexually in red blood cells (RBCs) of their vertebrate host, while a subset differentiates into sexual stages (gametocytes) for mosquito transmission. Parasite replication and gametocyte maturation in the erythropoietic niches of the bone marrow and spleen contribute to pathogenesis and drive transmission, but the mechanisms underlying this organ enrichment remain unknown. Here, we performed a comprehensive analysis of rodent\n                    <jats:italic>P. berghei<\/jats:italic>\n                    infection by flow cytometry and single-cell RNA sequencing. We identified CD71 as a host receptor for reticulocyte invasion and found that parasites metabolically adapt to the host cell environment. Transcriptional analysis and functional assays further revealed a nutrient-dependent tropism for gametocyte formation in reticulocytes. Together, we provide a thorough characterization of host-parasite interactions in erythropoietic niches and define host cell maturation state as the key driver of parasite adaptation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abm7348","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:58:00Z","timestamp":1651067880000},"source":"Crossref","is-referenced-by-count":31,"title":["Host cell maturation modulates parasite invasion and sexual differentiation in\n                    <i>Plasmodium berghei<\/i>"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-0128","authenticated-orcid":true,"given":"Franziska","family":"Hentzschel","sequence":"first","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-044X","authenticated-orcid":true,"given":"Matthew P.","family":"Gibbins","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-6586","authenticated-orcid":true,"given":"Charalampos","family":"Attipa","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK."},{"name":"Department of Pathology, Kamuzu University of Health Sciences, Blantyre, Malawi."},{"name":"Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-5212","authenticated-orcid":true,"given":"Dario","family":"Beraldi","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-9393","authenticated-orcid":true,"given":"Christopher A.","family":"Moxon","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK."},{"name":"Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi."},{"name":"Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-7404","authenticated-orcid":true,"given":"Thomas D.","family":"Otto","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-9566","authenticated-orcid":true,"given":"Matthias","family":"Marti","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK."},{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization \u201cWHO | The World malaria report 2020\u201d 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