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Sexually divergent development of functional connectivity was located in the default mode network, limbic cortex, and subcortical nuclei. Females had a more \u201cdisruptive\u201d pattern of development, where weak functional connectivity at age 14 became stronger during adolescence. This fMRI-derived map of sexually divergent brain network development was robustly colocated with i prior loci of reward-related brain activation ii a map of functional dysconnectivity in major depressive disorder (MDD), and iii an adult brain gene transcriptional pattern enriched for genes on the X chromosome, neurodevelopmental genes, and risk genes for MDD. We found normative sexual divergence in adolescent development of a cortico-subcortical brain functional network that is relevant to depression.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abm7825","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T13:58:42Z","timestamp":1653659922000},"source":"Crossref","is-referenced-by-count":42,"title":["Sexually divergent development of depression-related brain networks during healthy human adolescence"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-1104","authenticated-orcid":true,"given":"Lena","family":"Dorfschmidt","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-0685","authenticated-orcid":true,"given":"Richard 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