{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:33:56Z","timestamp":1790645636321,"version":"4.1.0"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,5,6]]},"abstract":"<jats:p>\n                    Protozoan parasites that infect humans are widespread and lead to varied clinical manifestations, including life-threatening illnesses in immunocompromised individuals. Animal models have provided insight into innate immunity against parasitic infections; however, species-specific differences and complexity of innate immune responses make translation to humans challenging. Thus, there is a need for in vitro systems that can elucidate mechanisms of immune control and parasite dissemination. We have developed a human microphysiological system of intestinal tissue to evaluate parasite-immune\u2013specific interactions during infection, which integrates primary intestinal epithelial cells and immune cells to investigate the role of innate immune cells during epithelial infection by the protozoan parasite,\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    , which affects billions of people worldwide. Our data indicate that epithelial infection by parasites stimulates a broad range of effector functions in neutrophils and natural killer cell\u2013mediated cytokine production that play immunomodulatory roles, demonstrating the potential of our system for advancing the study of human-parasite interactions.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abm8012","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T14:01:47Z","timestamp":1651845707000},"source":"Crossref","is-referenced-by-count":35,"title":["Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-2725","authenticated-orcid":true,"given":"Mouhita","family":"Humayun","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 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