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We used a customized stoichiometric ratio of\n                    <jats:sc>l<\/jats:sc>\n                    -glutamic acid and\n                    <jats:sc>l<\/jats:sc>\n                    -lysine within an amphiphilic polymer of poly(\n                    <jats:sc>l<\/jats:sc>\n                    -glutamic acid-co-\n                    <jats:sc>l<\/jats:sc>\n                    -lysine), or P(Glu-co-Lys), to effect this transformation in acidotic environments. P(Glu-co-Lys)-GNRs were internalized by cancer cells to facilitate potent in vitro radiosensitization. When administered intravenously in mice, they accumulate in the periphery and core of tumors without any signs of serum biochemical or hematological alterations, normal organ histopathological abnormalities, or overt deterioration in animal health. 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