{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:08:02Z","timestamp":1791454082636,"version":"4.3.3"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,5,13]]},"abstract":"<jats:p>\n            Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for maintenance immunosuppression. We report a strategy through which cotransplantation of allogeneic islets and streptavidin (SA)\u2013FasL\u2013presenting microgels to the omentum under transient rapamycin monotherapy resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates for &gt;6 months. Surgical extraction of the graft resulted in prompt hyperglycemia. In contrast, animals receiving microgels without SA-FasL under the same rapamycin regimen rejected islet grafts acutely. Graft survival was associated with increased number of FoxP3\n            <jats:sup>+<\/jats:sup>\n            cells in the graft site with no significant changes in T cell systemic frequencies or responses to donor and third-party antigens, indicating localized tolerance. Recipients of SA-FasL microgels exhibited normal liver and kidney metabolic function, demonstrating safety. This localized immunomodulatory strategy succeeded with unmodified islets and does not require long-term immunosuppression, showing translational potential in \u03b2 cell replacement for treating type 1 diabetes.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abm9881","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T17:57:20Z","timestamp":1652464640000},"source":"Crossref","is-referenced-by-count":80,"title":["FasL microgels induce immune acceptance of islet allografts in nonhuman primates"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-2370","authenticated-orcid":true,"given":"Ji","family":"Lei","sequence":"first","affiliation":[{"name":"Center for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-7221","authenticated-orcid":true,"given":"Mar\u00eda 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