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In cells, this mutation is associated with higher levels of aSyn, accumulation of pS129, and increased toxicity. In a neuronal seeding model of Lewy body (LB) formation, the E83Q mutation significantly enhances the internalization of fibrils into neurons, induces higher seeding activity, and results in the formation of diverse aSyn pathologies, including the formation of LB-like inclusions that recapitulate the immunohistochemical and morphological features of brainstem LBs observed in brains of patients with Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1126\/sciadv.abn0044","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T17:58:46Z","timestamp":1651255126000},"source":"Crossref","is-referenced-by-count":51,"title":["A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4322-3963","authenticated-orcid":true,"given":"Senthil T.","family":"Kumar","sequence":"first","affiliation":[{"name":"Laboratory of 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