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To elucidate these principles, we visualized the growth of dendrites throughout larval development of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    sensory neurons and found that the tips of dendrites undergo dynamic instability, transitioning rapidly and stochastically between growing, shrinking, and paused states. By incorporating these measured dynamics into an agent-based computational model, we showed that the complex and highly variable dendritic morphologies of these cells are a consequence of the stochastic dynamics of their dendrite tips. These principles may generalize to branching of other neuronal cell types, as well as to branching at the subcellular and tissue levels.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abn0080","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T13:51:14Z","timestamp":1656510674000},"source":"Crossref","is-referenced-by-count":30,"title":["Dynamic instability of dendrite tips generates the highly branched morphologies of sensory neurons"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-8157","authenticated-orcid":true,"given":"Sonal","family":"Shree","sequence":"first","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5826-5891","authenticated-orcid":true,"given":"Sabyasachi","family":"Sutradhar","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-4801","authenticated-orcid":true,"given":"Olivier","family":"Trottier","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA."},{"name":"Department of Physics, Yale University, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhai","family":"Tu","sequence":"additional","affiliation":[{"name":"IBM T.J. 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