{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:03:45Z","timestamp":1788512625871,"version":"build-2803163510"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,4,8]]},"abstract":"<jats:p>\n            There is an increasingly growing demand for nonantibiotic strategies to overcome drug resistance in bacterial biofilm infections. Here, a novel \u201cgas-sensitized hyperthermia\u201d strategy is proposed for appreciable bacteria killing by the smart design of a metal-organic framework (MOF)\u2013sealed Prussian blue\u2013based nanocarrier (MSDG). Once the biofilm microenvironment (BME) is reached, the acidity-activated MOF degradation allows the release of diallyl trisulfide and subsequent glutathione-responsive generation of hydrogen sulfide (H\n            <jats:sub>2<\/jats:sub>\n            S) gas. Upon near-infrared irradiation, H\n            <jats:sub>2<\/jats:sub>\n            S-sensitized hyperthermia arising from MSDG can efficiently eliminate biofilms through H\n            <jats:sub>2<\/jats:sub>\n            S-induced extracellular DNA damage and heat-induced bacterial death. The generated H\n            <jats:sub>2<\/jats:sub>\n            S in the biofilm can stimulate the polarization of macrophages toward M2 phenotype for reshaping immune microenvironment. Subsequently, the secretion of abundant regeneration-related cytokines from M2 macrophages accelerates tissue regeneration by reversing the infection-induced pro-inflammatory environment in an implant-related infection model. Collectively, such BME-responsive nano-antibacterials can achieve biofilm-specific H\n            <jats:sub>2<\/jats:sub>\n            S-sensitized thermal eradiation and immunomodulatory tissue remodeling, thus realizing the renaissance of precision treatment of refractory implant\u2013related infections.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abn1701","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T17:56:11Z","timestamp":1649440571000},"source":"Crossref","is-referenced-by-count":124,"title":["Bioresponsive nano-antibacterials for H\n            <sub>2<\/sub>\n            S-sensitized hyperthermia and immunomodulation against refractory implant\u2013related infections"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-9441","authenticated-orcid":true,"given":"Zheng","family":"Su","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5686-1710","authenticated-orcid":true,"given":"Lingtong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-0226","authenticated-orcid":true,"given":"Jin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Qian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-0793","authenticated-orcid":true,"given":"Yuanyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 DingJiaQiao Road, Nanjing 210009, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, 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