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The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases.<\/jats:p>","DOI":"10.1126\/sciadv.abn1772","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:57:25Z","timestamp":1648663045000},"source":"Crossref","is-referenced-by-count":91,"title":["Biodegradable silicon nanoneedles for ocular drug delivery"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-3104","authenticated-orcid":true,"given":"Woohyun","family":"Park","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-1483","authenticated-orcid":true,"given":"Van Phuc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, 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