{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:07:36Z","timestamp":1792552056797,"version":"4.5.0"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:p>\n            The striatum plays a critical role in regulating addiction-related behaviors. The conventional dichotomy model suggests that striatal D1\/D2 medium spiny neurons (MSNs) positively\/negatively regulate addiction-related behaviors. However, this model does not account for the neuronal heterogeneity and functional diversity of the striatum, and whether MSN subtypes beyond the pan-D1\/D2 populations play distinct roles in drug addiction remains unknown. We characterized the role of a\n            <jats:italic>tachykinin 2<\/jats:italic>\n            \u2013expressing D1 MSN subtype (\n            <jats:italic>\n              Tac2\n              <jats:sup>+<\/jats:sup>\n            <\/jats:italic>\n            ), present in both rodent and primate striatum, using cocaine addiction mouse models. We found that acute cocaine administration reduces\n            <jats:italic>Tac2<\/jats:italic>\n            neuronal activity, and cocaine conditioning alters neuronal response related to cocaine reward contextual associations. In addition, activation\/inhibition of\n            <jats:italic>\n              Tac2\n              <jats:sup>+<\/jats:sup>\n            <\/jats:italic>\n            neurons attenuates\/promotes cocaine-induced conditioned place preference and cocaine intravenous self-administration. Furthermore, stimulation of the NAc-to-lateral hypothalamic projection of\n            <jats:italic>\n              Tac2\n              <jats:sup>+<\/jats:sup>\n            <\/jats:italic>\n            neurons suppresses cocaine reward behavior. Our study reveals an unconventional negative regulatory function of D1 MSNs in drug addiction that operates in a subtype- and projection-specific manner.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abn3552","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T17:58:21Z","timestamp":1660327101000},"source":"Crossref","is-referenced-by-count":52,"title":["A molecularly defined D1 medium spiny neuron subtype negatively regulates cocaine addiction"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-9118","authenticated-orcid":true,"given":"Zheng-dong","family":"Zhao","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Division of Hematology\/Oncology, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Division of Hematology\/Oncology, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-7192","authenticated-orcid":true,"given":"Renchao","family":"Chen","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Division of Hematology\/Oncology, Department of Pediatrics, Boston Children\u2019s Hospital, 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