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The 5xTCD condensates display much stronger actin-bundling ability than those without Gpsm2-G\u03b1i, which may provide critical insights into how Gpsm2-G\u03b1i specifies the tallest stereocilia. A deafness-associated mutation of Gpsm2 leads to impaired formation of the 5xTCD condensates and consequently reduced actin bundling, providing possible clues for etiology of hearing loss in patients with Chudley-McCullough syndrome.<\/jats:p>","DOI":"10.1126\/sciadv.abn4556","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T17:58:20Z","timestamp":1654883900000},"source":"Crossref","is-referenced-by-count":19,"title":["Promotion of row 1\u2013specific tip complex condensates by Gpsm2-G\u03b1i provides insights into row identity of the tallest stereocilia"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-780X","authenticated-orcid":true,"given":"Yingdong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of USTC, Ministry of Education Key Laboratory for Cellular Dynamics, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-446X","authenticated-orcid":true,"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-2780","authenticated-orcid":true,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of USTC, Ministry of Education Key Laboratory for Cellular Dynamics, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-0143","authenticated-orcid":true,"given":"Jinwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-04-0940"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.24.13336"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033142"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(85)90010-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033167"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200310055"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20199"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1219"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001048"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.12.005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1444"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1208"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108770"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.12.046"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.09.011"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2819"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1242\/dev.139089","article-title":"A link between planar polarity and staircase-like bundle architecture in hair cells","volume":"143","author":"Tarchini B.","year":"2016","unstructured":"B. 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