{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:55:40Z","timestamp":1791482140420,"version":"4.3.4"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,6,10]]},"abstract":"<jats:p>\n            Glucagon-like peptide-1 (GLP-1) regulates energy homeostasis via activation of the GLP-1 receptors (GLP-1Rs) in the central nervous system. However, the mechanism by which the central GLP-1 signal controls blood glucose levels, especially in different nutrient states, remains unclear. Here, we defined a population of glucose-sensing GLP-1R neurons in the dorsomedial hypothalamic nucleus (DMH), by which endogenous GLP-1 decreases glucose levels via the cross-talk between the hypothalamus and pancreas. Specifically, we illustrated the sufficiency and necessity of DMH\n            <jats:sup>GLP-1R<\/jats:sup>\n            in glucose regulation. The activation of the DMH\n            <jats:sup>GLP-1R<\/jats:sup>\n            neurons is mediated by a cAMP-PKA\u2013dependent inhibition of a delayed rectifier potassium current. We also dissected a descending control of DMH\n            <jats:sup>GLP-1R<\/jats:sup>\n            \u2013dorsal motor nucleus of the vagus nerve (DMV)\u2013pancreas activity that can regulate glucose levels by increasing insulin release. Thus, our results illustrate how central GLP-1 action in the DMH can induce a nutrient state\u2013dependent reduction in blood glucose level.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abn5345","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T17:52:26Z","timestamp":1654710746000},"source":"Crossref","is-referenced-by-count":80,"title":["Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-5089","authenticated-orcid":true,"given":"Zhaohuan","family":"Huang","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Anhui, China."},{"name":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 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