{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:48:37Z","timestamp":1788518917938,"version":"build-2803163510"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,9,23]]},"abstract":"<jats:p>\n            Severe COVID-19 is associated with hyperinflammation and weak T cell responses against SARS-CoV-2. However, the links between those processes remain partially characterized. Moreover, whether and how therapeutically manipulating T cells may benefit patients are unknown. Our genetic and pharmacological evidence demonstrates that the ion channel TMEM176B inhibited inflammasome activation triggered by SARS-CoV-2 and SARS-CoV-2\u2013related murine \u03b2-coronavirus.\n            <jats:italic>\n              Tmem176b\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            mice infected with murine \u03b2-coronavirus developed inflammasome-dependent T cell dysfunction and critical disease, which was controlled by modulating dysfunctional T cells with PD-1 blockers. In critical COVID-19, inflammasome activation correlated with dysfunctional T cells and low monocytic TMEM176B expression, whereas PD-L1 blockade rescued T cell functionality. Here, we mechanistically link T cell dysfunction and inflammation, supporting a cancer immunotherapy to reinforce T cell immunity in critical \u03b2-coronavirus disease.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abn6545","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T17:58:34Z","timestamp":1663783114000},"source":"Crossref","is-referenced-by-count":24,"title":["PD-1\/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical \u03b2-coronavirus disease"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-5974","authenticated-orcid":true,"given":"Maite","family":"Duhalde Vega","sequence":"first","affiliation":[{"name":"Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, 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