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Using a circuit-breaking screen and targeted neuron ablations, we show that cerebellar granule cells and a cluster of glutamatergic ventral prepontine neurons (vPPNs) that express key stress-associated neuropeptides are critical components of the circuit that suppresses movement. The complete sensorimotor circuit transmits information from sensory ganglia through the cerebellum to vPPNs to regulate reticulospinal premotor neurons. These results show that cerebellar regulation of a neuropeptide-rich prepontine structure governs a conserved and ancestral defensive behavior that is triggered by an inescapable threat.<\/jats:p>","DOI":"10.1126\/sciadv.abo0549","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:58:26Z","timestamp":1664373506000},"source":"Crossref","is-referenced-by-count":16,"title":["A cerebellar-prepontine circuit for tonic immobility triggered by an inescapable threat"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-1594","authenticated-orcid":true,"given":"Ashwin A.","family":"Bhandiwad","sequence":"first","affiliation":[{"name":"Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-7788","authenticated-orcid":true,"given":"Nickolas C.","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-4142","authenticated-orcid":true,"given":"Svetlana A.","family":"Semenova","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-2192","authenticated-orcid":true,"given":"George A.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-7801","authenticated-orcid":true,"given":"Harold A.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(01)00016-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0197"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.03.058"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.048"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05875-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03394432"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000065"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.5127\/jep.051915"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0206"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17996"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54302"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00265-017-2436-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.025"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03394435"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490020108"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.06.017"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110110"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.140"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","unstructured":"M. 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