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To overcome these limitations, we developed a nanotherapeutic that effectively prevents ROP development with one simple intravenous injection. Its lipid nanocapsules transport the antiangiogenic and anti-inflammatory cyclosporin A efficiently into disease-driving retinal pigment epithelium cells. In a mouse model of ROP, a single intravenous injection of the nanotherapeutic prevented ROP and led to normal retinal development by counteracting neovascularization and inflammation. This nanotherapeutic approach has the potential to bring about a change of paradigm in ROP therapy and prevent millions of preterm born infants from developing ROP.<\/jats:p>","DOI":"10.1126\/sciadv.abo6638","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T18:00:29Z","timestamp":1663956029000},"source":"Crossref","is-referenced-by-count":23,"title":["A single intravenous injection of cyclosporin A\u2013loaded lipid nanocapsules prevents retinopathy of prematurity"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-1723","authenticated-orcid":true,"given":"Marilena","family":"Bohley","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, University of Regensburg, 93053 Regensburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E.","family":"Dillinger","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Embryology, University of Regensburg, 93053 Regensburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schweda","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Regensburg, 93053 Regensburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ohlmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Munich University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara M.","family":"Braunger","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Julius-Maximilians-University of Wuerzburg, 97070 Wuerzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6679-8743","authenticated-orcid":true,"given":"Ernst R.","family":"Tamm","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Embryology, University of Regensburg, 93053 Regensburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-0252","authenticated-orcid":true,"given":"Achim","family":"Goepferich","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, University of Regensburg, 93053 Regensburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.04.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2019.08.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.050"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0943-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30818-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60458-X"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S94436"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2584"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30489-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"e_1_3_2_16_2","first-page":"5836","article-title":"VEGF is required for neuroretina survival and function","volume":"49","author":"Maharaj A. 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