{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:34:18Z","timestamp":1791326058923,"version":"4.3.1"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,6,17]]},"abstract":"<jats:p>Rabies infection is nearly 100% lethal if untreated and kills more than 50,000 people annually, many of them children. Existing rabies vaccines target the rabies virus glycoprotein (RABV-G) but generate short-lived immune responses, likely because the protein is heterogeneous under physiological conditions. Here, we report the 3.39 \u00c5 cryo\u2013electron microscopy structure of trimeric, prefusion RABV-G complexed with RVA122, a potently neutralizing human antibody. RVA122 binds to a quaternary epitope at the top of RABV-G, bridging domains and stabilizing RABV-G protomers in a prefusion state. RABV-G trimerization involves side-to-side interactions between the central \u03b1 helix and adjacent loops, rather than contacts between central helices, and interactions among the fusion loops at the glycoprotein base. These results provide a basis from which to develop improved rabies vaccines based on RABV-G stabilized in the prefusion conformation.<\/jats:p>","DOI":"10.1126\/sciadv.abp9151","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T17:58:22Z","timestamp":1655488702000},"source":"Crossref","is-referenced-by-count":70,"title":["Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-3854","authenticated-orcid":true,"given":"Heather M.","family":"Callaway","sequence":"first","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-469X","authenticated-orcid":true,"given":"Dawid","family":"Zyla","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-4263","authenticated-orcid":true,"given":"Florence","family":"Larrous","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Unit of Lyssavirus Epidemiology and Neuropathology, World Health Organization Collaborating Centre for Reference and Research on Rabies, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-7760","authenticated-orcid":true,"given":"Guilherme Dias","family":"de Melo","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Unit of Lyssavirus Epidemiology and Neuropathology, World Health Organization Collaborating Centre for Reference and Research on Rabies, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-1210","authenticated-orcid":true,"given":"Kathryn M.","family":"Hastie","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-7153","authenticated-orcid":true,"given":"Ruben Diaz","family":"Avalos","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-1034","authenticated-orcid":true,"given":"Alyssa","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-1364","authenticated-orcid":true,"given":"Davide","family":"Corti","sequence":"additional","affiliation":[{"name":"Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-5589","authenticated-orcid":true,"given":"Herv\u00e9","family":"Bourhy","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Unit of Lyssavirus Epidemiology and Neuropathology, World Health Organization Collaborating Centre for Reference and Research on Rabies, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-7451","authenticated-orcid":true,"given":"Erica Ollmann","family":"Saphire","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA."},{"name":"Department of Medicine, University of California San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"e0003709","DOI":"10.1371\/journal.pntd.0003709","article-title":"Global Alliance for Rabies Control Partners for Rabies Prevention, Estimating the global burden of endemic canine rabies","volume":"9","author":"Hampson K.","year":"2015","unstructured":"K. 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