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Here, we introduce a bioresorbable nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disappears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.<\/jats:p>","DOI":"10.1126\/sciadv.abp9169","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T13:57:20Z","timestamp":1664978240000},"source":"Crossref","is-referenced-by-count":109,"title":["A bioresorbable peripheral nerve stimulator for electronic pain block"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-4092","authenticated-orcid":true,"given":"Geumbee","family":"Lee","sequence":"first","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA."},{"name":"Precision Biology Research Center, Sungkyunkwan University, Suwon 16419, Republic of 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