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It has been verified that ZVMNs can down-regulate the quantity of ROS and reduce colitis in a mouse IBD model without distinct side effects. In addition, RNA sequencing reveals a further mechanism that the ZVMNs can protect colon tissues from oxidative stress by inhibiting the nuclear factor \u03baB signaling pathway and reducing the production of excessive pro-inflammatory factors. Together, the ZVMNs will offer a promising alternative treatment option for patients suffering from IBD.<\/jats:p>","DOI":"10.1126\/sciadv.abp9882","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T13:58:17Z","timestamp":1663336697000},"source":"Crossref","is-referenced-by-count":111,"title":["Oral zero-valent-molybdenum nanodots for inflammatory bowel disease therapy"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-7181","authenticated-orcid":true,"given":"Chen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-5928","authenticated-orcid":true,"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. 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China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-6233","authenticated-orcid":true,"given":"Weiguo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Center on Aging of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. 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