{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:13:39Z","timestamp":1790666019468,"version":"4.1.0"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,11,16]]},"abstract":"<jats:p>\n                    Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A\u2013dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains unknown. Here, we show that exposure to nCB particles increased PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    PD-L2\n                    <jats:sup>+<\/jats:sup>\n                    CD206\n                    <jats:sup>+<\/jats:sup>\n                    antigen-presenting cells (APCs), exhausted T cells, and T\n                    <jats:sub>reg<\/jats:sub>\n                    cells. Lung macrophages that harbored nCB particles showed selective mitochondrial structure damage and decreased oxidative respiration. Lung macrophages sustained the HIF1\u03b1 axis that increased glycolysis and lactate production, culminating in an immunosuppressive microenvironment in multiple mouse models of non\u2013small cell lung cancers. Adoptive transfer of lung APCs from nCB-exposed wild type to susceptible mice increased tumor incidence and caused early metastasis. Our findings show that nCB exposure metabolically rewires lung macrophages to promote immunosuppression and accelerates the development of lung cancer.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abq0615","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T13:58:34Z","timestamp":1668607114000},"source":"Crossref","is-referenced-by-count":75,"title":["Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-3044","authenticated-orcid":true,"given":"Cheng-Yen","family":"Chang","sequence":"first","affiliation":[{"name":"Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"You","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-0911","authenticated-orcid":true,"given":"Dominique","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-1309","authenticated-orcid":true,"given":"Ashwini","family":"Bandi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8288-0707","authenticated-orcid":true,"given":"Yi-Ting","family":"Cheng","sequence":"additional","affiliation":[{"name":"Developmental Biology Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-6532","authenticated-orcid":true,"given":"Philip M.","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-9402","authenticated-orcid":true,"given":"Luis","family":"Becerra-Dominguez","sequence":"additional","affiliation":[{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Madison","sequence":"additional","affiliation":[{"name":"Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ying","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-7310","authenticated-orcid":true,"given":"Yifan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-7795","authenticated-orcid":true,"given":"Lizhen","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Cytometry and Cell Sorting Core, Baylor College of Medicine, Houston TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Porter","sequence":"additional","affiliation":[{"name":"Cytometry and Cell Sorting Core, Baylor College of Medicine, Houston TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-6893","authenticated-orcid":true,"given":"John M.","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-7400","authenticated-orcid":true,"given":"Nagireddy","family":"Putluri","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-6495","authenticated-orcid":true,"given":"Xiaoyi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela C.","family":"Marcano","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-9328","authenticated-orcid":true,"given":"James M.","family":"Tour","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3572-7598","authenticated-orcid":true,"given":"Andre","family":"Catic","sequence":"additional","affiliation":[{"name":"Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Developmental Biology Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-5395","authenticated-orcid":true,"given":"Laure","family":"Maneix","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan M.","family":"Burt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Division of Thoracic Surgery, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-046X","authenticated-orcid":true,"given":"Hyun-Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Division of Thoracic Surgery, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-1016","authenticated-orcid":true,"given":"David B.","family":"Corry","sequence":"additional","affiliation":[{"name":"Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-103X","authenticated-orcid":true,"given":"Farrah","family":"Kheradmand","sequence":"additional","affiliation":[{"name":"Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","unstructured":"\u201c7 Million premature deaths annually linked to air pollution \u201d World Health Organization 25 March 2014."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702747"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30505-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2013.06.009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000792"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09623"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3292"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx166"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003041"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.01.028"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106102"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128106"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3704"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.20"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.09.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3535"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03045-2"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1457"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202702"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.019"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.006"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.014"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2597"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13490"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-035972"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3006"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26410"},{"key":"e_1_3_3_29_2","first-page":"17","article-title":"Role of PD-1 in regulating T-cell immunity","volume":"350","author":"Jin H. T.","year":"2011","unstructured":"H. T. Jin, R. Ahmed, T. Okazaki, Role of PD-1 in regulating T-cell immunity. Curr. Top. Microbiol. Immunol. 350, 17\u201337 (2011).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090737"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3216"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranlsmed.3000154"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040620"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22625"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1545CI"},{"key":"e_1_3_3_37_2","first-page":"672","article-title":"The potential effects of burn pit exposure on the respiratory tract: A systematic review","volume":"186","author":"McLean J.","year":"2021","unstructured":"J. McLean, D. Anderson, G. Capra, C. A. Riley, The potential effects of burn pit exposure on the respiratory tract: A systematic review. Mil. Med. 186, 672\u2013681 (2021).","journal-title":"Mil. Med."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.018"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100587"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002202"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.004"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124317"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01143"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0384-2"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3655"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000430306"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.01.001"},{"key":"e_1_3_3_49_2","first-page":"420","article-title":"Metabolic reprograming in macrophage polarization","volume":"5","author":"Galvan-Pena S.","year":"2014","unstructured":"S. Galvan-Pena, L. A. O\u2019Neill, Metabolic reprograming in macrophage polarization. Front. Immunol. 5, 420 (2014).","journal-title":"Front. Immunol."},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.014"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.011"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40579-6"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.12.011"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1509171"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101422"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12858-016-0069-6"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-9-5"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11654-3"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006724"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.001"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0554"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0352-y"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021417"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abq0615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T17:54:02Z","timestamp":1704822842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abq0615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":63,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2022,11,16]]}},"alternative-id":["10.1126\/sciadv.abq0615"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abq0615","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]},"article-number":"eabq0615"}}