{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:42:45Z","timestamp":1790847765888,"version":"4.1.0"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,11,4]]},"abstract":"<jats:p>\n            Astrocyte abnormalities have received great attention for their association with various diseases in the brain but not so much in the eye. Recent independent genome-wide association studies of glaucoma, optic neuropathy characterized by retinal ganglion cell (RGC) degeneration, and vision loss found that single-nucleotide polymorphisms near the ABCA1 locus were common risk factors. Here, we show that\n            <jats:italic>Abca1<\/jats:italic>\n            loss in retinal astrocytes causes glaucoma-like optic neuropathy in aged mice. ABCA1 was highly expressed in retinal astrocytes in mice. Thus, we generated macroglia-specific\n            <jats:italic>Abca1<\/jats:italic>\n            -deficient mice (Glia-KO) and found that aged Glia-KO mice had RGC degeneration and ocular dysfunction without affected intraocular pressure, a conventional risk factor for glaucoma. Single-cell RNA sequencing revealed that\n            <jats:italic>Abca1<\/jats:italic>\n            deficiency in aged Glia-KO mice caused astrocyte-triggered inflammation and increased the susceptibility of certain RGC clusters to excitotoxicity. Together, astrocytes play a pivotal role in eye diseases, and loss of ABCA1 in astrocytes causes glaucoma-like neuropathy.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abq1081","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T17:58:48Z","timestamp":1667584728000},"source":"Crossref","is-referenced-by-count":33,"title":["Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-1304","authenticated-orcid":true,"given":"Youichi","family":"Shinozaki","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan."},{"name":"GLIA Center, University of Yamanashi, Yamanashi, 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