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Neuroinflammation contributes to the pathophysiology of synucleinopathies, including Parkinson\u2019s disease, multiple system atrophy, and dementia with Lewy bodies. This review aims to summarize the neuroinflammatory response of glial cells and vascular cells in the NVU. We also review neuroinflammation in the context of the cross-talk between glial cells and vascular cells, between glial cells and pericytes, and between microglia and astroglia. Last, we discuss how \u03b1-synuclein affects neuroinflammation and how neuroinflammation influences the aggregation and spread of \u03b1-synuclein and analyze different properties of \u03b1-synuclein in synucleinopathies.<\/jats:p>","DOI":"10.1126\/sciadv.abq1141","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T13:58:43Z","timestamp":1676469523000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":76,"title":["The link between neuroinflammation and the neurovascular unit in synucleinopathies"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-6540","authenticated-orcid":true,"given":"Qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-7103","authenticated-orcid":true,"given":"Jialing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-3738","authenticated-orcid":true,"given":"Sven","family":"Pettersson","sequence":"additional","affiliation":[{"name":"ASEAN Microbiome Nutrition Centre, National Neuroscience Institute, Singapore 308433, Singapore."},{"name":"Karolinska Institutet, Department of Odontology, 171 77 Solna, Sweden."},{"name":"Faculty of Medical Sciences, Sunway University, Subang Jaya, 47500 Selangor, Malaysia."},{"name":"Department of Microbiology and Immunology, National University Singapore, Singapore 117545, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-4694","authenticated-orcid":true,"given":"Richard","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London W12 0NN, UK."},{"name":"Centre for Molecular Neuropathology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-4805","authenticated-orcid":true,"given":"Eng-King","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Duke-NUS Medical School, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"},{"key":"e_1_3_1_3_2","first-page":"72","article-title":"Synucleinopathies","volume":"26","author":"Coon E. 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