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In response to lipopolysaccharide (LPS), ACC is required for the early metabolic switch to glycolysis and remodeling of the macrophage lipidome. ACC deficiency also resulted in impaired macrophage innate immune functions, including bacterial clearance. Myeloid-specific deletion or pharmacological inhibition of ACC in mice attenuated LPS-induced expression of proinflammatory cytokines interleukin-6 (IL-6) and IL-1\u03b2, while pharmacological inhibition of ACC increased susceptibility to bacterial peritonitis in wild-type mice. Together, we identify a critical role for ACC in metabolic regulation of the innate immune response in macrophages, and thus a clinically relevant, unexpected consequence of pharmacological ACC inhibition.<\/jats:p>","DOI":"10.1126\/sciadv.abq1984","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T18:59:28Z","timestamp":1669229968000},"source":"Crossref","is-referenced-by-count":96,"title":["Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-7157","authenticated-orcid":true,"given":"Scott","family":"Yeudall","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-3394","authenticated-orcid":true,"given":"Clint M.","family":"Upchurch","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-4670","authenticated-orcid":true,"given":"Philip V.","family":"Seegren","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin M.","family":"Pavelec","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."},{"name":"Robert M. 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