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Inhibitors of ATM-Chk2, but not the parallel ATR-Chk1 pathway, also promote marked, functional recovery after acute central nervous system injury in rats, suggesting that inhibiting nonhomologous end-joining rather than homologous recombination is crucial for neuroprotection. We demonstrate that the Chk2 inhibitor, prexasertib, which has been evaluated in phase 2 clinical trials for cancer, has potent neuroprotective effects and represents a new treatment option to promote functional recovery after spinal cord or optic nerve injury.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abq2611","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T17:59:54Z","timestamp":1663178394000},"source":"Crossref","is-referenced-by-count":28,"title":["Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-4453","authenticated-orcid":true,"given":"Matthew J.","family":"Taylor","sequence":"first","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharif","family":"Alhajlah","sequence":"additional","affiliation":[{"name":"Applied Medical Science College, Shaqra University, Addawadmi, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-6254","authenticated-orcid":true,"given":"Richard I.","family":"Tuxworth","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-6442","authenticated-orcid":true,"given":"Zubair","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."},{"name":"Centre for Trauma Sciences Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.11.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0210-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.07.029"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108297"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3546"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.05.015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0530-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.5.1007"},{"key":"e_1_3_3_10_2","first-page":"1933","article-title":"Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer\u2019s disease","volume":"150","author":"McShea A.","year":"1997","unstructured":"A. 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