{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:02:41Z","timestamp":1791504161154,"version":"4.3.4"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"49","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,12,9]]},"abstract":"<jats:p>\n            Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows that glia can independently induce such responses. Here, we show that overexpression of heat shock factor 1 (\n            <jats:italic>hsf-1<\/jats:italic>\n            ) in the four astrocyte-like cephalic sheath cells of\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            induces a non\u2013cell-autonomous cytosolic unfolded protein response, also known as the heat shock response (HSR). These animals have increased lifespan and heat stress resistance and decreased protein aggregation. Glial HSR regulation is independent of canonical thermosensory circuitry and known neurotransmitters but requires the small clear vesicle release protein UNC-13. HSF-1 and the FOXO transcription factor DAF-16 are partially required in peripheral tissues for non\u2013cell-autonomous HSR, longevity, and thermotolerance. Cephalic sheath glial\n            <jats:italic>hsf-1<\/jats:italic>\n            overexpression also leads to pathogen resistance, suggesting a role for this signaling pathway in immune function.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abq3970","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T18:58:20Z","timestamp":1670612300000},"source":"Crossref","is-referenced-by-count":29,"title":["Glia of\n            <i>C. elegans<\/i>\n            coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-890X","authenticated-orcid":true,"given":"Holly K.","family":"Gildea","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-3422","authenticated-orcid":true,"given":"Phillip A.","family":"Frankino","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-046X","authenticated-orcid":true,"given":"Sarah U.","family":"Tronnes","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-3079","authenticated-orcid":true,"given":"Corinne L.","family":"Pender","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-7332","authenticated-orcid":true,"given":"Jenni","family":"Durieux","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-6141","authenticated-orcid":true,"given":"Julian G.","family":"Dishart","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-7712","authenticated-orcid":true,"given":"Hyun Ok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9171-3169","authenticated-orcid":true,"given":"Tayla D.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Biology, Howard University, Washington, DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-4687","authenticated-orcid":true,"given":"Shannon S.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-0770","authenticated-orcid":true,"given":"Ashley E.","family":"Frakes","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-4266","authenticated-orcid":true,"given":"Edward","family":"Sukarto","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-8499","authenticated-orcid":true,"given":"Kevin","family":"Wickham","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-2629","authenticated-orcid":true,"given":"Andrew","family":"Dillin","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA."},{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.06.027"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.042"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.026"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.12.016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.12.020"},{"key":"e_1_3_3_7_2","first-page":"1392","article-title":"Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress","volume":"13","author":"Sarge K. D.","year":"1993","unstructured":"K. D.\u00a0Sarge, S. P.\u00a0Murphy, R. I.\u00a0Morimoto,Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol. Cell. Biol.13,1392\u20131407 (1993).","journal-title":"Mol. Cell. Biol."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006849"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14405"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156093"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.029"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.11.040"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/376344a0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aan4893"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01087-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(91)90128-K"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02774-3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz6896"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24463"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050314"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020578"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.05.003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1143762"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.335422.119"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/01677063.2020.1781851"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.08.021"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1466-07.2007"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/14755"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200512190-00005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225815"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.283317.116"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108154200"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-48"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030039"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15458"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604050103"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.042"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108489"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03960-y"},{"key":"e_1_3_3_40_2","doi-asserted-by":"crossref","unstructured":"F. Wang H.\u00a0B.\u00a0Bradshaw S.\u00a0Pena B.\u00a0Jablonska J.\u00a0Xavier S.\u00a0Gong B.\u00a0Li D.\u00a0Chandler-Militello L.\u00a0K.\u00a0Bekar N.\u00a0A.\u00a0Smith Calcium-independent astrocytic lipid release modulates neuronal excitability. bioRxiv 903393 [ Preprint ]. 31 March 2021. https:\/\/doi.org\/10.1101\/2020.01.12.903393.","DOI":"10.1101\/2020.01.12.903393"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.001"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09581-4"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00548"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/88850"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.21.3434"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/161.3.1101"},{"key":"e_1_3_3_48_2","first-page":"e61001","article-title":"Measurements of physiological stress responses in C. elegans","volume":"2020","author":"Bar-Ziv R.","year":"2020","unstructured":"R.\u00a0Bar-Ziv, A. E.\u00a0Frakes, R.\u00a0Higuchi-Sanabria, T.\u00a0Bolas, P. A.\u00a0Frankino, H. K.\u00a0Gildea, M. G.\u00a0Metcalf, A.\u00a0Dillin,Measurements of physiological stress responses in C. elegans. J. Vis. Exp.2020,e61001 (2020).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw343"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr064"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv416"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2016.11.005"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh012"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abq3970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T22:41:26Z","timestamp":1704840086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abq3970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":52,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2022,12,9]]}},"alternative-id":["10.1126\/sciadv.abq3970"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abq3970","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,9]]},"article-number":"eabq3970"}}