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For some lines, 18\u00a0hours\/day of cytostatic hypothermia was sufficient to halt division in vitro. Next, we fabricated an experimental tool to test local cytostatic hypothermia in two rodent GBM models. Hypothermia more than doubled median survival, and all rats that successfully received cytostatic hypothermia survived their study period. Unlike targeted therapeutics that are successful in preclinical models but fail in clinical trials, cytostatic hypothermia leverages fundamental physics that influences biology broadly. It is a previously unexplored approach that could provide an additional option to patients with GBM by halting tumor growth.<\/jats:p>","DOI":"10.1126\/sciadv.abq4882","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T13:58:26Z","timestamp":1669384706000},"source":"Crossref","is-referenced-by-count":20,"title":["Cytostatic hypothermia and its impact on glioblastoma and survival"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-6809","authenticated-orcid":true,"given":"Syed Faaiz","family":"Enam","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27705, USA."},{"name":"Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem Y.","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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