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We examined effects of CA4 in mice on ASIC-mediated synaptic transmission in medium spiny neurons (MSNs) in NAc, as well as on cocaine-induced synaptic changes and behavior. We found that CA4 is expressed in the NAc and present in synaptosomes. Disrupting CA4 either globally, or locally, increased ASIC-mediated synaptic currents in NAc MSNs and protected against cocaine withdrawal\u2013induced changes in synapses and cocaine-seeking behavior. These findings raise the possibility that CA4 might be a previously unidentified therapeutic target for addiction and relapse.<\/jats:p>","DOI":"10.1126\/sciadv.abq5058","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T18:58:34Z","timestamp":1668625114000},"source":"Crossref","is-referenced-by-count":10,"title":["Carbonic anhydrase 4 disruption decreases synaptic and behavioral adaptations induced by cocaine withdrawal"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-4649","authenticated-orcid":true,"given":"Subhash C.","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA, USA."},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghobbeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa 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