{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:33:54Z","timestamp":1789403634051,"version":"build-2803163510"},"reference-count":90,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"23","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,6,9]]},"abstract":"<jats:p>\n            Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [\n            <jats:sup>18<\/jats:sup>\n            F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell\u2013mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [\n            <jats:sup>18<\/jats:sup>\n            F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell\u2013mediated ALE.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abq7595","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T17:58:28Z","timestamp":1686333508000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell\u2013mediated limbic encephalitis"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4954-8420","authenticated-orcid":true,"given":"Marco","family":"Gallus","sequence":"first","affiliation":[{"name":"Department of Neurology Institute of Translational Neurology, University of M\u00fcnster, M\u00fcnster, Germany."},{"name":"Department of Neurosurgery, University of M\u00fcnster, M\u00fcnster, Germany."},{"name":"Department of Neurosurgery, University of California, San\u00a0Francisco, San\u00a0Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-9393","authenticated-orcid":true,"given":"Wolfgang","family":"Roll","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4695-4136","authenticated-orcid":true,"given":"Andre","family":"Dik","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Translational Neurology, University of M\u00fcnster, M\u00fcnster, Germany."},{"name":"Department of Neurology, Medical Faculty, Heinrich Heine University of D\u00fcsseldorf, D\u00fcsseldorf, 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