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Fibroblasts invaded as individual cells and established a multicellular network, which transited to a two-compartment fibrotic response displaying an \u03b1SMA cold external capsule and a long-lasting, inner \u03b1SMA hot environment. The recruitment of fibroblasts and extent of fibrosis were only incompletely inhibited after depletion of macrophages, implicating coexistence of macrophage-dependent and macrophage-independent mediators. Furthermore, neither altering material type or porosity modulated \u03b1SMA\n            <jats:sup>+<\/jats:sup>\n            cell recruitment and distribution. This identifies fibroblast activation and network formation toward a two-compartment FBR as a conserved, self-organizing process partially independent of macrophages.\n          <\/jats:p>","DOI":"10.1126\/sciadv.add0014","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T18:58:26Z","timestamp":1671649106000},"source":"Crossref","is-referenced-by-count":24,"title":["Dissecting the recruitment and self-organization of \u03b1SMA-positive fibroblasts in the foreign body response"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-5527","authenticated-orcid":true,"given":"Maria","family":"Parlani","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medical Oncology and David H.\u00a0Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."},{"name":"Radboud University Medical Center, Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-3049","authenticated-orcid":true,"given":"Matthew L.","family":"Bedell","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7264-2614","authenticated-orcid":true,"given":"Antonios G.","family":"Mikos","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-4041","authenticated-orcid":true,"given":"Peter","family":"Friedl","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medical Oncology and David H.\u00a0Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."},{"name":"Radboud University Medical Center, Nijmegen, Netherlands."},{"name":"Cancer Genomics Centre (CGC.nl), 3584 Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-5418","authenticated-orcid":true,"given":"Eleonora","family":"Dondossola","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medical Oncology and David H.\u00a0Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.08.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70058-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200504"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma8095269"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4290"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3462"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.236075"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00760"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw041"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4866"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801451"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071794"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.73"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93555"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162488599"},{"key":"e_1_3_2_18_2","first-page":"2795","article-title":"A role for pericytes as microenvironmental regulators of human skin tissue regeneration","volume":"119","author":"Paquet-Fifield S.","year":"2009","unstructured":"S. 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