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Using in vivo functional approaches combined with molecular mechanistic analysis, we identified a reciprocal regulatory loop between B cell lymphoma 6 (Bcl6) and the RhoA-regulated transcriptional complex megakaryoblastic leukemia\/serum response factor (MKL\/SRF). We show that Bcl6 physically interacts with MKL\/SRF, resulting in a down-regulation of the transcriptional activity of both Bcl6 and MKL\/SRF. This molecular cross-talk is essential for the control of proliferation, neurogenesis, and spatial positioning of neural progenitors. Overall, our data highlight a regulatory mechanism that controls neuronal production and neocortical development and reveal an MKL\/SRF and Bcl6 interaction that may have broader implications in other physiological functions and in diseases.<\/jats:p>","DOI":"10.1126\/sciadv.add0676","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:58:28Z","timestamp":1700074708000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["MKL\/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1070-5446","authenticated-orcid":true,"given":"Alexia","family":"Cossard","sequence":"first","affiliation":[{"name":"Laboratory of Mammalian Development and Cell Biology, Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels 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