{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:58:16Z","timestamp":1791989896939,"version":"4.4.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"40","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,10,7]]},"abstract":"<jats:p>\n                    The cleavage and functionalization of recalcitrant carbon\u2500carbon bonds is highly challenging but represents a very powerful tool for value-added transformation of feedstock chemicals. Here, an enzyme-mimic iron single-atom catalyst (SAC) bearing iron (III) nitride (FeN\n                    <jats:sub>3<\/jats:sub>\n                    ) motifs was prepared and found to be robust for cleavage and cyanation of carbon\u2013carbon bonds in secondary alcohols and ketones. High nitrile yields are obtained with a wide variety of functional groups. The prepared FeN\n                    <jats:sub>3<\/jats:sub>\n                    -SAC exhibits high enzyme-like activity and is capable of generating a dioxygen-to-superoxide radical at room temperature, while the commonly reported FeN\n                    <jats:sub>4<\/jats:sub>\n                    -SAC bearing FeN\n                    <jats:sub>4<\/jats:sub>\n                    motifs was inactive. Density functional theory (DFT) calculation reveals that the activation energy of dioxygen activation and the activation energy of the rate-determining step of nitrile formation are lower over FeN\n                    <jats:sub>3<\/jats:sub>\n                    -SAC than FeN\n                    <jats:sub>4<\/jats:sub>\n                    -SAC. In addition, DFT calculation also explains the catalyst\u2019s high selectivity for nitriles.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.add1267","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T13:58:32Z","timestamp":1665151112000},"source":"Crossref","is-referenced-by-count":109,"title":["An enzyme-mimic single Fe-N\n                    <sub>3<\/sub>\n                    atom catalyst for the oxidative synthesis of nitriles via C\u2500C bond cleavage strategy"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7311-6272","authenticated-orcid":true,"given":"Jingzhong","family":"Qin","sequence":"first","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[{"name":"Sustainable Energy Laboratory, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-5215","authenticated-orcid":true,"given":"Wen","family":"Dai","sequence":"additional","affiliation":[{"name":"Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Luo","sequence":"additional","affiliation":[{"name":"Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"Nie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensheng","family":"Xian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-2191","authenticated-orcid":true,"given":"Zehui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Materials Sciences of the Ministry of Education, South-Central University for Nationalities, Wuhan 430074, P. R. 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