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Biomechanical, radiological, histological, and immunohistochemical analysis confirmed functional bone regeneration comparable to a clinical gold standard control (autologous bone graft) and was superior to a scaffold control group (mPCL-TCP only). Affirmative bone regeneration results from a pilot study using an XL size defect volume (19 cm\n            <jats:sup>3<\/jats:sup>\n            ) subsequently supported clinical translation. A 27-year-old adult male underwent reconstruction of a 36-cm near-total intercalary tibial defect secondary to osteomyelitis using the RMAV approach. Robust bone regeneration led to complete independent weight bearing within 24 months. This article demonstrates the widely advocated and seldomly accomplished concept of \u201cbench-to-bedside\u201d research and has weighty implications for reconstructive surgery and regenerative medicine more generally.\n          <\/jats:p>","DOI":"10.1126\/sciadv.add6071","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:58:17Z","timestamp":1683309497000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":52,"title":["Convergence of scaffold-guided bone regeneration principles and microvascular tissue transfer surgery"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-3770","authenticated-orcid":true,"given":"David S.","family":"Sparks","sequence":"first","affiliation":[{"name":"Centre for Biomedical Technologies, School of Mechanical, Medical, and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, QLD, 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