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We obtained the high-quality genome of\n            <jats:italic>Spirostomum minus<\/jats:italic>\n            from which we identified the key molecular components of its contractile apparatus, including two major Ca\n            <jats:sup>2+<\/jats:sup>\n            binding proteins (Spasmin 1 and 2) and two giant proteins (GSBP1 and GSBP2), which act as the backbone and allow for the binding of hundreds of spasmins. The evidence suggests that the GSBP-spasmin protein complex is the functional unit of the mesh-like contractile fibrillar system, which, coupled with various other subcellular structures, provides the mechanism for repetitive ultrafast cell contraction and extension. These findings improve our understanding of the Ca\n            <jats:sup>2+<\/jats:sup>\n            -dependent ultrafast movement and provide a blueprint for future biomimicry, design, and construction of this kind of micromachine.\n          <\/jats:p>","DOI":"10.1126\/sciadv.add6550","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T18:57:21Z","timestamp":1677092241000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["Giant proteins in a giant cell: Molecular basis of ultrafast Ca\n            <sup>2+<\/sup>\n            -dependent cell contraction"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-2184","authenticated-orcid":true,"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, 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