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Rather, the predominant macrophage signature in dystrophic muscle was characterized by high expression of fibrotic factors, galectin-3 (gal-3) and osteopontin (\n                    <jats:italic>Spp1<\/jats:italic>\n                    ). Spatial transcriptomics, computational inferences of intercellular communication, and in vitro assays indicated that macrophage-derived Spp1 regulates stromal progenitor differentiation. Gal-3\n                    <jats:sup>+<\/jats:sup>\n                    macrophages were chronically activated in dystrophic muscle, and adoptive transfer assays showed that the gal-3\n                    <jats:sup>+<\/jats:sup>\n                    phenotype was the dominant molecular program induced within the dystrophic milieu. Gal-3\n                    <jats:sup>+<\/jats:sup>\n                    macrophages were also elevated in multiple human myopathies. These studies advance our understanding of macrophages in muscular dystrophy by defining their transcriptional programs and reveal\n                    <jats:italic>Spp1<\/jats:italic>\n                    as a major regulator of macrophage and stromal progenitor interactions.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.add9984","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T13:58:42Z","timestamp":1688738322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":156,"title":["Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-9706","authenticated-orcid":true,"given":"Gerald","family":"Coulis","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 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