{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:01:53Z","timestamp":1778900513006,"version":"3.51.4"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"17","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,4,26]]},"abstract":"<jats:p>\n                    While the kinesin-2 motors KIF3A and KIF3B have essential roles in ciliogenesis and Hedgehog (HH) signal transduction, potential role(s) for another kinesin-2 motor, KIF17, in HH signaling have yet to be explored. Here, we investigated the contribution of KIF17 to HH-dependent cerebellar development, where\n                    <jats:italic>Kif17<\/jats:italic>\n                    is expressed in both HH-producing Purkinje cells and HH-responding cerebellar granule neuron progenitors (CGNPs). Germline\n                    <jats:italic>Kif17<\/jats:italic>\n                    deletion in mice results in cerebellar hypoplasia due to reduced CGNP proliferation, a consequence of decreased HH pathway activity mediated through decreased Sonic HH (SHH) protein. Notably, Purkinje cell\u2013specific\n                    <jats:italic>Kif17<\/jats:italic>\n                    deletion partially phenocopies\n                    <jats:italic>Kif17<\/jats:italic>\n                    germline mutants. Unexpectedly, CGNP-specific\n                    <jats:italic>Kif17<\/jats:italic>\n                    deletion results in the opposite phenotype\u2014increased CGNP proliferation and HH target gene expression due to altered GLI transcription factor processing. Together, these data identify KIF17 as a key regulator of HH-dependent cerebellar development, with dual and opposing roles in HH-producing Purkinje cells and HH-responding CGNPs.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ade1650","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T13:58:41Z","timestamp":1714139921000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Dual and opposing roles for the kinesin-2 motor, KIF17, in Hedgehog-dependent cerebellar development"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-5985","authenticated-orcid":true,"given":"Bridget","family":"Waas","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-1926","authenticated-orcid":true,"given":"Brandon S.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, College of Science and Mathematics, Kennesaw State University, Kennesaw, GA, 30061, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-0061","authenticated-orcid":true,"given":"Nicole E.","family":"Franks","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia Q.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen J.","family":"Verhey","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2323-8313","authenticated-orcid":true,"given":"Benjamin L.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.14.3089"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80682-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.03.007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02351"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.04.017"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01438"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.05.015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028175"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81705-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.4.825"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02061"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.02.026"},{"key":"e_1_3_2_14_2","first-page":"1034","article-title":"The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function","volume":"128","author":"Carpenter B. 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