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Their incorporation enabled recognition of nonubiquitin targets by host ubiquitin ligases. We find that SCF<jats:sup>FBW7<\/jats:sup>E3 ligase, supported by the regulatory kinase, glycogen synthase kinase 3\u03b2, is crucial for effective pathogen detection and clearance. This provides a mechanistic explanation for enhanced risk of infections in patients with chronic lymphocytic leukemia bearing mutations in F-box and WD repeat domain containing 7 protein. We conclude that exploitation of this generic pathogen sensing strategy allows conservation of host resources and boosts antimicrobial immunity.<\/jats:p>","DOI":"10.1126\/sciadv.ade1851","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T18:01:34Z","timestamp":1679508094000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-9667","authenticated-orcid":true,"given":"Shruti","family":"Apte","sequence":"first","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, 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