{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:36:45Z","timestamp":1789832205506,"version":"4.0.1"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"18","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,5,5]]},"abstract":"<jats:p>\n            Pathogenic short tandem repeat (STR) expansions cause over 20 neurodegenerative diseases. To determine the contribution of STRs in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), we used ExpansionHunter, REviewer, and polymerase chain reaction validation to assess 21 neurodegenerative disease-associated STRs in whole-genome sequencing data from 608 patients with sporadic ALS, 68 patients with sporadic FTD, and 4703 matched controls. We also propose a data-derived outlier detection method for defining allele thresholds in rare STRs. Excluding\n            <jats:italic>C9orf72<\/jats:italic>\n            repeat expansions, 17.6% of clinically diagnosed ALS and FTD cases had at least one expanded STR allele reported to be pathogenic or intermediate for another neurodegenerative disease. We identified and validated 162 disease-relevant STR expansions in\n            <jats:italic>C9orf72<\/jats:italic>\n            (ALS\/FTD),\n            <jats:italic>ATXN1<\/jats:italic>\n            [spinal cerebellar ataxia type 1 (SCA1)],\n            <jats:italic>ATXN2<\/jats:italic>\n            (SCA2),\n            <jats:italic>ATXN8<\/jats:italic>\n            (SCA8),\n            <jats:italic>TBP<\/jats:italic>\n            (SCA17),\n            <jats:italic>HTT<\/jats:italic>\n            (Huntington\u2019s disease),\n            <jats:italic>DMPK<\/jats:italic>\n            [myotonic dystrophy type 1 (DM1)],\n            <jats:italic>CNBP<\/jats:italic>\n            (DM2), and\n            <jats:italic>FMR1<\/jats:italic>\n            (fragile-X disorders). Our findings suggest clinical and pathological pleiotropy of neurodegenerative disease genes and highlight their importance in ALS and FTD.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ade2044","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:58:17Z","timestamp":1683309497000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":38,"title":["Short tandem repeat expansions in sporadic amyotrophic lateral sclerosis and frontotemporal dementia"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-7637","authenticated-orcid":true,"given":"Lyndal","family":"Henden","sequence":"first","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-5411","authenticated-orcid":true,"given":"Liam G.","family":"Fearnley","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia."},{"name":"Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-7706","authenticated-orcid":true,"given":"Natalie","family":"Grima","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-3525","authenticated-orcid":true,"given":"Emily P.","family":"McCann","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-0257","authenticated-orcid":true,"given":"Carol","family":"Dobson-Stone","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."},{"name":"School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Friend","sequence":"additional","affiliation":[{"name":"SA Pathology, Women\u2019s and Children\u2019s Hospital, North Adelaide, SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Hobson","sequence":"additional","affiliation":[{"name":"SA Pathology, Women\u2019s and Children\u2019s Hospital, North Adelaide, SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6304-0283","authenticated-orcid":true,"given":"Sandrine","family":"Chan Moi Fat","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-2146","authenticated-orcid":true,"given":"Dominic B.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."},{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-6716","authenticated-orcid":true,"given":"Susan","family":"D\u2019Silva","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."},{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9574-6195","authenticated-orcid":true,"given":"John B.","family":"Kwok","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."},{"name":"School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-8398","authenticated-orcid":true,"given":"Glenda M.","family":"Halliday","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."},{"name":"School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-026X","authenticated-orcid":true,"given":"Matthew C.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."},{"name":"Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5322-5543","authenticated-orcid":true,"given":"Srestha","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-1625","authenticated-orcid":true,"given":"Hannah C.","family":"Timmins","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Zoing","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-7273","authenticated-orcid":true,"given":"Roger","family":"Pamphlett","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia."},{"name":"Discipline of Pathology, The University of Sydney, Sydney, NSW 2050, Australia."},{"name":"Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorel","family":"Adams","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-0774","authenticated-orcid":true,"given":"Melanie","family":"Bahlo","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia."},{"name":"Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-0075","authenticated-orcid":true,"given":"Ian P.","family":"Blair","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-9473","authenticated-orcid":true,"given":"Kelly L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01201-x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.03.011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00382-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00737-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105156"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.04.005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09363-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-322983"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009398"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr195"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00042"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315995"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09320"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.11.011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.11.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02385-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28341"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2020-106866"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00684"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.207464"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2044"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027985"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3622"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00973-1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70043-1"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.225672.117"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz431"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2579-z"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00462-2"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01085-z"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0423"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.05.016"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0458-z"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa064"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6430-9"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-018-0998-2"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117260"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00318"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102021"},{"key":"e_1_3_3_45_2","first-page":"6886","article-title":"Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation","volume":"24","author":"Coyne A. N.","year":"2015","unstructured":"A. N.\u00a0Coyne, S. B.\u00a0Yamada, B. B.\u00a0Siddegowda, P. S.\u00a0Estes, B. L.\u00a0Zaepfel, J. S.\u00a0Johannesmeyer, D. B.\u00a0Lockwood, L. T.\u00a0Pham, M. P.\u00a0Hart, J. A.\u00a0Cassel, B.\u00a0Freibaum, A. V.\u00a0Boehringer, J. P.\u00a0Taylor, A. B.\u00a0Reitz, A. D.\u00a0Gitler, D. C.\u00a0Zarnescu, Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Hum. Mol. Genet. 24, 6886\u20136898 (2015).","journal-title":"Hum. Mol. Genet."},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.158261"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32987"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3233\/JND-150088"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114095"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12973"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005996"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.13980.1"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.10.017"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1005-5"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5237-9"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab472"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00434-z"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bf997a"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06159-4"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-020-00139-8"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02168"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.255"},{"key":"e_1_3_3_66_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ana.21948","article-title":"RNA-mediated neurodegeneration in repeat expansion disorders","volume":"67","author":"Todd P. K.","year":"2010","unstructured":"P. K.\u00a0Todd, H. L.\u00a0Paulson, RNA-mediated neurodegeneration in repeat expansion disorders. Ann. Neurol. 67, 291\u2013300 (2010).","journal-title":"Ann. Neurol."},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.024"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200656"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.11.010"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-35"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.11.1809"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2013.9.4.274"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.14.1441"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.019"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.06.007"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldx034"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010945"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.03.007"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000333665.01888.33"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.ade2044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:35:37Z","timestamp":1704836137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ade2044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":78,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2023,5,5]]}},"alternative-id":["10.1126\/sciadv.ade2044"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.ade2044","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"2022-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eade2044"}}