{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:40:57Z","timestamp":1780634457130,"version":"3.54.1"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:p>\n            Mice with SHP1 proteins, which have a single amino acid substitution from tyrosine-208 residue to asparagine (hereafter\n            <jats:italic>Ptpn6<\/jats:italic>\n            <jats:sup>spin<\/jats:sup>\n            mice), develop an autoinflammatory disease with inflamed footpads. Genetic crosses to study CD47 function in\n            <jats:italic>Ptpn6<\/jats:italic>\n            <jats:sup>spin<\/jats:sup>\n            mice bred\n            <jats:italic>Ptpn6<\/jats:italic>\n            <jats:sup>spin<\/jats:sup>\n            \u00d7\n            <jats:italic>Cd47<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice that were not born at the expected Mendelian ratio.\n            <jats:italic>Ptpn6<\/jats:italic>\n            <jats:sup>spin<\/jats:sup>\n            bone marrow cells, when transferred into lethally irradiated\n            <jats:italic>Cd47<\/jats:italic>\n            -deficient mice, caused marked weight loss and subsequent death. At a cellular level,\n            <jats:italic>Ptpn6<\/jats:italic>\n            -deficient neutrophils promoted weight loss and death of the lethally irradiated\n            <jats:italic>Cd47<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            recipients. We posited that leakage of gut microbiota promotes morbidity and mortality in\n            <jats:italic>Cd47<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice receiving\n            <jats:italic>Ptpn6<\/jats:italic>\n            <jats:sup>spin<\/jats:sup>\n            cells. Colonic cell death and gut leakage were substantially increased in the diseased\n            <jats:italic>Cd47<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice. Last, IL-1 blockade using anakinra rescued the morbidity and mortality observed in the diseased\n            <jats:italic>Cd47<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice. These data together demonstrate a protective role for CD47 in tempering pathogenic neutrophils in the\n            <jats:italic>Ptpn6<\/jats:italic>\n            <jats:sup>spin<\/jats:sup>\n            mice.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ade3942","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T21:36:19Z","timestamp":1674250579000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["CD47 halts\n            <i>Ptpn6<\/i>\n            -deficient neutrophils from provoking lethal inflammation"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-3705","authenticated-orcid":true,"given":"Lalita","family":"Mazgaeen","sequence":"first","affiliation":[{"name":"Inflammation Program, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-9367","authenticated-orcid":true,"given":"Matthew","family":"Yorek","sequence":"additional","affiliation":[{"name":"Inflammation Program, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8312-3521","authenticated-orcid":true,"given":"Saurabh","family":"Saini","sequence":"additional","affiliation":[{"name":"Inflammation Program, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-0545","authenticated-orcid":true,"given":"Peter","family":"Vogel","sequence":"additional","affiliation":[{"name":"Animal Resources Center and the Veterinary Pathology Core, St.\u00a0Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-3253","authenticated-orcid":true,"given":"David K.","family":"Meyerholz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-6443","authenticated-orcid":true,"given":"Thirumala-Devi","family":"Kanneganti","sequence":"additional","affiliation":[{"name":"Department of Immunology, St.\u00a0Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7451-9433","authenticated-orcid":true,"given":"Prajwal","family":"Gurung","sequence":"additional","affiliation":[{"name":"Inflammation Program, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Immunology Graduate Program, University of Iowa, Iowa City, IA 52241, USA."},{"name":"Center for Immunology and Immune-Based Disease, University of Iowa, Iowa City, IA 52241, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-34"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0202-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0251-7"},{"key":"e_1_3_3_5_2","first-page":"265","article-title":"Neutrophilic dermatoses: A broad spectrum of disease","volume":"153","author":"Filosa A.","year":"2018","unstructured":"A.\u00a0Filosa, G.\u00a0Filosa,Neutrophilic dermatoses: A broad spectrum of disease. 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