{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:30:18Z","timestamp":1790253018450,"version":"4.1.0"},"reference-count":65,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"14","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,4,7]]},"abstract":"<jats:p>\n                    The liver plays a protective role in myocardial infarction (MI). However, very little is known about the mechanisms. Here, we identify mineralocorticoid receptor (MR) as a pivotal nexus that conveys communications between the liver and the heart during MI. Hepatocyte\n                    <jats:italic>MR<\/jats:italic>\n                    deficiency and MR antagonist spironolactone both improve cardiac repair after MI through regulation on hepatic fibroblast growth factor 21 (FGF21), illustrating an MR\/FGF21 axis that underlies the liver-to-heart protection against MI. In addition, an upstreaming acute interleukin-6 (IL-6)\/signal transducer and activator of transcription 3 (STAT3) pathway transmits the heart-to-liver signal to suppress MR expression after MI. Hepatocyte\n                    <jats:italic>Il6<\/jats:italic>\n                    receptor deficiency and\n                    <jats:italic>Stat3<\/jats:italic>\n                    deficiency both aggravate cardiac injury through their regulation on the MR\/FGF21 axis. Therefore, we have unveiled an IL-6\/STAT3\/MR\/FGF21 signaling axis that mediates heart-liver cross-talk during MI. Targeting the signaling axis and the cross-talk could provide new strategies to treat MI and heart failure.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ade4110","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T13:58:37Z","timestamp":1680703117000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":74,"title":["An IL-6\/STAT3\/MR\/FGF21 axis mediates heart-liver cross-talk after myocardial infarction"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-1524","authenticated-orcid":true,"given":"Jian-Yong","family":"Sun","sequence":"first","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China."},{"name":"National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-5672","authenticated-orcid":true,"given":"Lin-Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China."},{"name":"National Center for Stomatology; 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