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In neonatal humans and zebrafish larvae, CPSF6 insufficiency shifts poly(A) site usage between the 3\u2032UTR and internal sites in a pathway-specific manner. Genes associated with neuronal function undergo mostly intronic APA, reducing their expression, while genes associated with heart and skeletal function mostly undergo 3\u2032UTR APA and are up-regulated. This suggests that, under healthy conditions, cells toggle between internal and 3\u2032UTR APA to modulate protein expression.<\/jats:p>","DOI":"10.1126\/sciadv.ade4814","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T13:58:22Z","timestamp":1676642302000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":35,"title":["Alternative polyadenylation alters protein dosage by switching between intronic and 3\u2032UTR sites"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-2541","authenticated-orcid":true,"given":"Nicola","family":"de Prisco","sequence":"first","affiliation":[{"name":"Department of Genetics and Development, Columbia University Irving Medical Center, New\u00a0York, NY, USA."},{"name":"Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New\u00a0York, NY, 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