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Oral administration of mEVs restores gut barrier integrity at multiple levels, including mucus, epithelial, and immune barriers, and prevents endotoxin translocation into the liver in chemical-induced experimental colitis and diet-induced nonalcoholic steatohepatitis (NASH), thereby alleviating gut disorders, their associated liver inflammation, and NASH. Oral administration of mEVs has potential in the treatment of gut inflammation and gut-liver axis\u2013associated metabolic diseases via protection of intestinal barrier integrity.<\/jats:p>","DOI":"10.1126\/sciadv.ade5041","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T13:58:31Z","timestamp":1681307911000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":237,"title":["Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-8657","authenticated-orcid":true,"given":"Lingjun","family":"Tong","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, P.\u00a0R.\u00a0China."},{"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore,, 1E Kent 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