{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:24:44Z","timestamp":1789431884610,"version":"build-2803163510"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,1,27]]},"abstract":"<jats:p>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells specific for cereal gluten proteins are key players in celiac disease (CeD) pathogenesis. While several CeD-relevant gluten T cell epitopes have been identified, epitopes recognized by a substantial proportion of gluten-reactive T cells remain unknown. The identification of such CeD-driving gluten epitopes is important for the food industry and in clinical settings. Here, we have combined the knowledge of a distinct phenotype of gluten-reactive T cells and key features of known gluten epitopes for the discovery of unknown  epitopes. We tested 42 wheat gluten\u2013reactive T cell clones, isolated on the basis of their distinct phenotype and with no reactivity to known epitopes, against a panel of synthetic peptides bioinformatically identified from a wheat gluten protein database. We were able to assign reactivity to 10 T cell clones and identified a 9-nucleotide oligomer core region of five previously uncharacterized gliadin\/glutenin epitopes. This work represents an advance in the effort to identify CeD-driving gluten epitopes.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ade5800","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T13:58:27Z","timestamp":1674655107000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Identification of gluten T cell epitopes driving celiac disease"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-3106","authenticated-orcid":true,"given":"Mark\u00e9ta","family":"Chlubnov\u00e1","sequence":"first","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Center, University of Oslo, Oslo, Norway."},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-807X","authenticated-orcid":true,"given":"Asbj\u00f8rn O.","family":"Christophersen","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Center, University of Oslo, Oslo, Norway."},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Rheumatology, Dermatology, and Infectious Diseases, Oslo University Hospital, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4959-1409","authenticated-orcid":true,"given":"Geir Kjetil F.","family":"Sandve","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Center, University of Oslo, Oslo, Norway."},{"name":"Department of Informatics, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-5545","authenticated-orcid":true,"given":"Knut E.A","family":"Lundin","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Center, University of Oslo, Oslo, Norway."},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Gastroenterology, Oslo University Hospital Rikshospitalet, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0419-2914","authenticated-orcid":true,"given":"J\u00f8rgen","family":"Jahnsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-5098","authenticated-orcid":true,"given":"Shiva","family":"Dahal-Koirala","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Center, University of Oslo, Oslo, Norway."},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-704X","authenticated-orcid":true,"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Center, University of Oslo, Oslo, Norway."},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Immunology, Oslo University Hospital, Oslo, 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