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While CAdVEC caused no significant toxicities, it repolarized the tumor microenvironment with increased infiltration of CD8 T cells. A single administration of CAdVEC was associated with both locoregional and abscopal effects on metastases and, in combination with systemic administration of immune checkpoint antibodies, induced sustained antitumor responses, including one complete and two partial responses. Hence, in both preclinical and clinical studies, CAdVEC is safe and even at extremely low doses is sufficiently potent to induce significant tumor control through oncolysis and immune repolarization.<\/jats:p>","DOI":"10.1126\/sciadv.ade6790","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T14:02:09Z","timestamp":1681135329000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Ultralow-dose binary oncolytic\/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-8652","authenticated-orcid":true,"given":"Daniel","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX, 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