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While D is characterized by early activation of innate immune responses, in SDp there is rapid expansion and activation of IgG-secreting plasma cells and memory and regulatory T cells. Concurrently, SDp, particularly children, demonstrate increased proinflammatory NK cells, inadequate expansion of CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes, and high expression of the Fc\u03b3R CD64 on myeloid cells, yet a signature of diminished antigen presentation. Syndrome-specific determinants include suppressed dendritic cell abundance in shock\/hemorrhage versus enriched plasma cell expansion in organ impairment. This study reveals uncoordinated immune responses in SDp and provides insights into SD pathogenesis in humans with potential implications for prediction and treatment.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ade7702","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T13:59:15Z","timestamp":1679666355000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":32,"title":["Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-4159","authenticated-orcid":true,"given":"Makeda L.","family":"Robinson","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 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