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Here, we report an effective method for the preparation of phosphacycles through nickel-catalyzed [4+2] heteroannulation of internal alkynes with aminophosphanes derived from\n            <jats:italic>o<\/jats:italic>\n            -haloanilines. Notably, chiral 2-\u03bb5-phosphaquinolines can be prepared from P-stereogenic substrates via NH\/PH tautomeric equilibrium without loss of stereochemical integrity. The strategy is found to exhibit a broad scope in terms of both reaction components, enabling modular construction of libraries of 2-\u03bb5-phosphaquinolines with different steric and electronic properties for fine-tuning photophysical properties, where some of these compounds showed distinct fluorescence with high quantum yields. A series of mechanistic studies further shed light on the pathway of the heteroannulation and reasons for stereospecificity.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ade8638","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T18:59:11Z","timestamp":1673636351000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Stereospecific nickel-catalyzed [4+2] heteroannulation of alkynes with aminophosphanes"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-3029","authenticated-orcid":true,"given":"Ronghui","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, 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