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In Ad5-\u0394V, core components did not readily diffuse out of partially disrupted capsids, and the core appeared more condensed than in Ad5-wt. These observations suggest that instead of condensing the genome, protein V antagonizes the condensing action of the other core proteins. Protein V provides mechanical reinforcement and facilitates genome release by keeping DNA connected to capsid fragments that detach during disruption. This scenario is in line with the location of protein V in the virion and its role in Ad5 cell entry.<\/jats:p>","DOI":"10.1126\/sciadv.ade9910","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T17:58:26Z","timestamp":1680890306000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Adenovirus core protein V reinforces the capsid and enhances genome release from disrupted particles"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-404X","authenticated-orcid":true,"given":"Natalia","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Departament of Condensed Matter Physics, Universidad Aut\u00f3noma de Madrid and Institute of Condensed Matter Physics (IFIMAC), 28049 Madrid, 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