{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:16:19Z","timestamp":1792631779269,"version":"4.5.0"},"reference-count":83,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"17","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,4,28]]},"abstract":"<jats:p>\n                    Although most mammals heal injured tissues and organs with scarring, spiny mice (\n                    <jats:italic>Acomys<\/jats:italic>\n                    ) naturally regenerate skin and complex musculoskeletal tissues. Now, the core signaling pathways driving mammalian tissue regeneration are poorly characterized. Here, we show that, while immediate extracellular signal-regulated kinase (ERK) activation is a shared feature of scarring (\n                    <jats:italic>Mus<\/jats:italic>\n                    ) and regenerating (\n                    <jats:italic>Acomys<\/jats:italic>\n                    ) injuries, ERK activity is only sustained at high levels during complex tissue regeneration. Following ERK inhibition, ear punch regeneration in\n                    <jats:italic>Acomys<\/jats:italic>\n                    shifted toward fibrotic repair. Using single-cell RNA sequencing, we identified ERK-responsive cell types. Loss- and gain-of-function experiments prompted us to uncover fibroblast growth factor and ErbB signaling as upstream ERK regulators of regeneration. The ectopic activation of ERK in scar-prone injuries induced a pro-regenerative response, including cell proliferation, extracellular matrix remodeling, and hair follicle neogenesis. Our data detail an important distinction in ERK activity between regenerating and poorly regenerating adult mammals and open avenues to redirect fibrotic repair toward regenerative healing.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adf2331","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:00:51Z","timestamp":1682517651000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":45,"title":["An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (\n                    <i>Acomys<\/i>\n                    )"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-1969","authenticated-orcid":true,"given":"Antonio","family":"Tomasso","sequence":"first","affiliation":[{"name":"Max Planck Institute for Molecular Biomedicine, R\u00f6ntgenstrasse 20, M\u00fcnster 48149, Germany."},{"name":"Cells in Motion Cluster of Excellence\u2014International Max Planck Research School (CiM-IMPRS Graduate Program), M\u00fcnster 48149, Germany."},{"name":"Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Uppsalalaan 8, Utrecht 3584CT, Netherlands."},{"name":"Department of Biology\/Chemistry, Osnabr\u00fcck University, Barbarastrasse 11, Osnabr\u00fcck 49076, Germany."},{"name":"Department of Biology, University of Kentucky, 101 T.H. Morgan Building, Lexington, KY 40506, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-3285","authenticated-orcid":true,"given":"Tim","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Uppsalalaan 8, Utrecht 3584CT, Netherlands."},{"name":"Department of Biology\/Chemistry, Osnabr\u00fcck University, Barbarastrasse 11, Osnabr\u00fcck 49076, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-583X","authenticated-orcid":true,"given":"Philip","family":"Lijnzaad","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht 3584 CS, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-4389","authenticated-orcid":true,"given":"Kerstin","family":"Bartscherer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Molecular Biomedicine, R\u00f6ntgenstrasse 20, M\u00fcnster 48149, Germany."},{"name":"Cells in Motion Cluster of Excellence\u2014International Max Planck Research School (CiM-IMPRS Graduate Program), M\u00fcnster 48149, Germany."},{"name":"Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Uppsalalaan 8, Utrecht 3584CT, Netherlands."},{"name":"Department of Biology\/Chemistry, Osnabr\u00fcck University, Barbarastrasse 11, Osnabr\u00fcck 49076, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-3664","authenticated-orcid":true,"given":"Ashley W.","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Kentucky, 101 T.H. 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