{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:43:12Z","timestamp":1793065392153,"version":"4.5.0"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"24","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,6,14]]},"abstract":"<jats:p>\n                    Fibrosis-associated fibroblasts have been identified across various fibrotic disorders, but not in the context of biomaterials, fibrotic encapsulation, and the foreign body response. In other fibrotic disorders, a fibroblast subpopulation defined by Thy-1 loss is strongly correlated with fibrosis yet we do not know what promotes Thy-1 loss. We have previously shown that Thy-1 is an integrin regulator enabling normal fibroblast mechanosensing, and here, leveraging nonfibrotic microporous annealed particle (MAP) hydrogels versus classical fibrotic bulk hydrogels, we demonstrate that\n                    <jats:italic>Thy1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice mount a fibrotic response to MAP gels that includes inflammatory signaling. We found that a distinct and cryptic \u03b1\u2013smooth muscle actin\u2013positive Thy-1\n                    <jats:sup>\u2212<\/jats:sup>\n                    fibroblast population emerges in response to interleuklin-1\u03b2 (IL-1\u03b2) and tumor necrosis factor\u2013\u03b1 (TNF\u03b1). Furthermore, IL-1\u03b2\/TNF\u03b1-induced Thy-1\n                    <jats:sup>\u2212<\/jats:sup>\n                    fibroblasts consist of two distinct subpopulations that are strongly proinflammatory. These findings illustrate the emergence of a unique proinflammatory, profibrotic fibroblast subpopulation that is central to fibrotic encapsulation of biomaterials.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adf2675","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T13:58:18Z","timestamp":1718373498000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["A Thy-1\u2013negative immunofibroblast population emerges as a key determinant of fibrotic outcomes to biomaterials"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6837-3028","authenticated-orcid":true,"given":"Daniel","family":"Abebayehu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Schools of Engineering and Medicine, University of Virginia, Charlottesville, VA 22908, USA."},{"name":"Robert Berne Cardiovascular Research Center, School of Medicine, 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